Inderal is a non-selective beta-blocker, which is used in cardiological practice for the therapy of diseases of the cardiovascular system. The primary active substance of Inderal is propranolol.
Indications for use
The drug is used in the form of tablets (10 mg, 40 mg) or a solution in ampoules to reduce blood pressure in hypertension and normalize blood pressure for a long time. This medication can be used for heart pain (angina pectoris) and coronary heart disease to reduce the burden on the heart. Inderal is able to treat tachycardia.
Inderal is taken orally in the form of tablets. The doctor should determine how often and in what dosage the drug should be taken. In some cases, the beta-blocker is administered intravenously.
Medication should not be used in case of: Myocardial insufficiency; Atrioventricular blockade II or III degree; Pronounced sinus bradycardia; Cardiovascular shock; Postponed apoplexy or infarction; Congenital hypotension; Asthma and chronic obstructive pulmonary disease; Severe forms of circulatory disorders in the hands and feet; Metabolic acidosis; Concomitant administration of calcium channel blockers administered through veins (such as verapamil or diltiazem); Concomitant use of monoamine oxidase inhibitors; Prolonged starvation; Severe psychoemotional or physical stress; Diabetes with abnormal fluctuations in blood glucose; Dysfunction of nephrons or liver; Severe allergy in history; Pheochromocytoma.
During pregnancy and lactation, Inderal should be used only after a thorough assessment of the health risks of the treating cardiologist.
The drug may be used in children only after a thorough medical evaluation of the benefits and harms of the doctor.
Common adverse reactions: Nausea and vomiting; Constipation; Diarrhea; Allergic skin reactions (redness, itching); Fatigue; Dizziness; Drowsiness; Confusion of consciousness; Nervousness; Sweating; Tremor; Headache; Insomnia; Depression.
Interaction and compatibility with other drugs
Simultaneous use of Inderal with insulin or other substances for the treatment of diabetes, the hypoglycemic effect can be enhanced. Therefore, regular checks of blood glucose level are necessary.
If Inderal is administered together with tricyclic antidepressants, barbiturates, phenothiazines, diuretics, drugs, vasodilators, glyceryl trinitrate and other antihypertensive agents, the pressure may increase. Co-administration of Inderal with calcium antagonists (e.g., nifedipine) can lead to a decrease in pressure.
The usage of Inderal and Verapamil require accurate medical monitoring of patients, as this can lead to low blood pressure, slow heartbeat and other cardiac arrhythmias.
The combination of Inder with cardiac glycosides and cerebral antihypertensive agents (reserpine, methyldopa, guanfacine, and clonidine) can lead to a more significant reduction in heart rate and a delay in cardiac activity.
After a sharp suspension of the use of clonidine and Inderal, blood pressure can rise dramatically. Therefore, clonidine should not be discontinued a few days before the end of the treatment with Inderal. Subsequently, clonidine can be withdrawn step by step. For this reason, Inderal is not recommended to be combined with MAO inhibitors. Adrenaline and norepinephrine can also increase blood pressure.
The concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, may reduce the antihypertensive effect of Inderal.
The combination of this drug with muscle relaxants, such as suxamethonium or tubocurarine, can enhance the effect of these substances.
Inderal therapy can reduce the effectiveness of adrenaline. If adrenaline is used to treat an allergic reaction, you may need to increase the dosage.